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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
43.03
Human Site:
Y494
Identified Species:
63.11
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
Y494
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
Y494
S
D
K
I
L
P
V
Y
E
Q
G
S
H
F
Q
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
Y494
S
D
K
I
L
P
V
Y
E
R
G
S
R
F
Q
Dog
Lupus familis
XP_546656
989
110956
Y494
S
D
K
T
L
P
V
Y
E
R
G
S
H
F
Q
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
Y494
S
D
K
L
L
P
V
Y
E
Q
G
S
H
F
Q
Rat
Rattus norvegicus
XP_002742497
1001
111922
Y492
S
D
K
L
L
P
V
Y
E
Q
G
F
R
F
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
Y537
S
D
K
V
I
P
I
Y
E
K
G
F
R
F
Q
Chicken
Gallus gallus
NP_001025807
1020
114626
Y496
S
D
K
V
I
P
L
Y
Q
K
G
S
R
F
Q
Frog
Xenopus laevis
NP_001085699
1022
114003
Y499
N
T
K
I
I
P
V
Y
E
M
G
A
Q
F
Q
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
Y492
Y
N
K
V
I
P
S
Y
S
P
N
T
T
F
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
Y487
S
A
K
Q
I
H
H
Y
E
N
G
Q
R
F
E
Honey Bee
Apis mellifera
XP_394050
958
109977
Y461
N
E
Q
K
I
H
N
Y
R
E
G
Q
V
F
K
Nematode Worm
Caenorhab. elegans
O61660
759
85420
D300
K
W
R
P
Q
A
L
D
T
V
E
L
E
K
L
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
P220
S
F
G
S
C
Q
F
P
T
L
G
F
V
V
E
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
S445
D
I
A
G
E
R
F
S
A
S
G
R
V
I
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
Y467
A
K
N
Y
L
E
V
Y
R
F
E
S
W
G
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
86.6
86.6
N.A.
93.3
80
N.A.
60
60
60
33.3
N.A.
40
20
0
13.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
86.6
N.A.
86.6
93.3
80
60
N.A.
53.3
60
13.3
20
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
0
0
7
0
0
7
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
50
0
0
0
0
0
7
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
7
7
0
0
57
7
13
0
7
0
13
% E
% Phe:
0
7
0
0
0
0
13
0
0
7
0
19
0
75
0
% F
% Gly:
0
0
7
7
0
0
0
0
0
0
82
0
0
7
7
% G
% His:
0
0
0
0
0
13
7
0
0
0
0
0
25
0
0
% H
% Ile:
0
7
0
25
38
0
7
0
0
0
0
0
0
7
0
% I
% Lys:
7
7
69
7
0
0
0
0
0
13
0
0
0
7
7
% K
% Leu:
0
0
0
13
44
0
13
0
0
7
0
7
0
0
13
% L
% Met:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% M
% Asn:
13
7
7
0
0
0
7
0
0
7
7
0
0
0
0
% N
% Pro:
0
0
0
7
0
63
0
7
0
7
0
0
0
0
0
% P
% Gln:
0
0
7
7
7
7
0
0
7
25
0
13
7
0
63
% Q
% Arg:
0
0
7
0
0
7
0
0
13
13
0
7
32
0
0
% R
% Ser:
63
0
0
7
0
0
7
7
7
7
0
44
0
0
0
% S
% Thr:
0
7
0
7
0
0
0
0
13
0
0
7
7
0
0
% T
% Val:
0
0
0
19
0
0
50
0
0
7
0
0
19
7
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
7
0
0
7
0
0
0
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _